Leptin: A Promising Therapeutic Target with Pleiotropic Action Besides Body Weight Regulation

Authors: Paraskevas, Kosmas I.¹; Liapis, Christos D.¹; Mikhailidis, Dimitri P.¹

Source: Current Drug Targets, Volume 7, Number 6, June 2006 , pp. 761-771(11)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Leptin seems to regulate various physiological mechanisms besides body weight. Leptin plays a role in vascular biology and pathology as well as renal function. In addition, leptin has been implicated in the regulation of fertility and reproduction.

The effect of pharmaceutical agents on circulating plasma leptin levels has been assessed. Among the drugs investigated are glitazones, statins, fibrates, serotonin reuptake inhibitors and cannabinoid-1 receptor antagonists. Since these agents are used to treat pathological conditions there is a potential role for leptin in these states.

The degree of involvement of leptin in several pathophysiological states needs to be defined to aid in the development of potentially useful therapeutic agents.

Keywords: Leptin; vascular biology; vascular disease; renal disease; fertility

Document Type: Research article

DOI: 10.2174/138945006777435371

Affiliations: 1: Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK.

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax Refund Policy