Authors: Paraskevas, Kosmas I.; Liapis, Christos D.; Mikhailidis, Dimitri P.

Source: Current Drug Targets, Volume 7, Number 6, June 2006 , pp. 761-771(11)

Publisher: Bentham Science Publishers

Abstract:

Leptin seems to regulate various physiological mechanisms besides body weight. Leptin plays a role in vascular biology and pathology as well as renal function. In addition, leptin has been implicated in the regulation of fertility and reproduction.

The effect of pharmaceutical agents on circulating plasma leptin levels has been assessed. Among the drugs investigated are glitazones, statins, fibrates, serotonin reuptake inhibitors and cannabinoid-1 receptor antagonists. Since these agents are used to treat pathological conditions there is a potential role for leptin in these states.

The degree of involvement of leptin in several pathophysiological states needs to be defined to aid in the development of potentially useful therapeutic agents.

Keywords: Leptin; vascular biology; vascular disease; renal disease; fertility

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138945006777435371

Affiliations: 1: Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK.

Publication date: 2006-06-01

More about this publication?

• Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

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