Authors: Daniel Abankwa; Patrick Kury

Source: Current Drug Targets, Volume 5, Number 7, October 2004 , pp. 647-654(8)

Publisher: Bentham Science Publishers

Abstract:

In contrast to the peripheral nervous system (PNS) nerve fiber tracts of the adult central nervous system (CNS) cannot spontaneously regenerate in response to lesions. As a result injured individuals suffer from chronically impaired neuronal connections leading to major motor-, sensory- and cognitive deficits. It is generally assumed that combinatorial effects account for this regeneration failure including a growth non-permissive environment within CNS lesion zones as well as incomplete activation of axonal growth programmes. In order to design CNS repair strategies it is, therefore, imperative to address the molecular mechanisms responsible for this abortive growth behaviour by means of large scale screening techniques. This review summarizes the outcome of recent gene expression profiling studies investigating local and remote molecular reactions following CNS axotomy.

Keywords: dna array technology; gene expression patterns; nerve regeneration; cns; pns; lesion site; axotomy; spinal cord injury

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389450043345182

Affiliations: 1: Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, Dusseldorf, Germany.

Publication date: 2004-10-01

More about this publication?

• Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

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