Streptogramin Antibiotics: Mode of Action and Resistance

Authors: Johnston N.J.; Mukhtar T.A.; Wright G.D.

Source: Current Drug Targets, Volume 3, Number 4, August 2002 , pp. 335-344(10)

Publisher: Bentham Science Publishers

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Abstract:

The streptogramin antibiotics were discovered over 40 years ago but are only now emerging as important therapeutic agents for the treatment of infection caused by a variety of bacteria. The streptogramins consist of mixtures of two structurally distinct compounds, type A and type B, which are separately bacteriostatic, but bactericidal in appropriate ratios. These antibiotics act at the level of inhibition of translation through binding to the bacterial ribosome. Resistance to streptogramins occurs through a number of mechanisms including target modification, efflux, and enzyme catalyzed antibiotic modification. This review describes the current understanding of streptogramin function and resistance with emphasis on molecular mechanism and epidemiology.

Keywords: Streptogramin Antibiotics; bacteriostatic; bactericidal

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389450023347678

Publication date: 2002-08-01

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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.