Insights into the Regulation of Renal Hemodynamic Function in Diabetic Mellitus

Authors: Cherney, David Z.I.; Scholey, James W.; Miller, Judith. A.

Source: Current Diabetes Reviews, Volume 4, Number 4, November 2008 , pp. 280-290(11)

Publisher: Bentham Science Publishers

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Abstract:

Diabetes mellitus (DM) is characterized by renal hemodynamic changes which have been purported to contribute to the development of nephropathy. In this review we have focused on the major renal hemodynamic factors that may be associated with glomerular hyperfiltration.

Recent animal and human studies have demonstrated that renal hemodynamic alterations occur very early in the natural history of DM. Most of the literature related to renal hemodynamic functional changes in type 1 DM has focused on major neurohormonal influences, such as the renin angiotensin system, cyclooxygenase-related pathways, the nitric oxide system, the autonomic nervous system and hyperglycemia. In addition, gender may have important modulatory effects on some of these putative pathways that have been implicated in the development of alterations in renal hemodynamic function related to DM.

Keywords: Diabetes mellitus; Gender; Renin angiotensin system; Cyclooxygenase 2; Prostaglandin; Nitric oxide; Hyperglycemia

Document Type: Research article

Publication date: 2008-11-01

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.