Candidate Genes Implicated in Type 1 Diabetes Susceptibility

Author: Aribi, Mourad

Source: Current Diabetes Reviews, Volume 4, Number 2, May 2008 , pp. 110-121(12)

Publisher: Bentham Science Publishers

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Abstract:

Type 1 diabetes (T1D) is an autoimmune disease resulting from pancreatic beta-cells destruction, often appearing on a genetic ground susceptibility under the influence of one or more environmental factors. Multiplex families studies, using genetic markers allowed the identification of various genes, including HLA, insulin, SUMO-4 and CTLA-4 all being linked with different degrees to disease risk. The MIF gene was also suggested, although its role has yet to be established on family or twin studies. The difference in susceptibility among T1D patients suggest the development of the disease as resulting from the interaction between genetic and environmental factors. This review emphasizes the importance of identifying the genes that have a direct impact on the autoimmune process, while recalling the different strategies that are followed. The style of writing should appeal to those with strong interests in molecular biology with an equal balance of immunology and molecular epidemiology.

Keywords: Candidate genes; Identification strategies; Type 1 diabetes susceptibility

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339908784220723

Publication date: 2008-05-01

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.