Advanced Glycation End Products and Cardiovascular Disease

Authors: Peppa, Melpomeni; Raptis, Sotirios A.

Source: Current Diabetes Reviews, Volume 4, Number 2, May 2008 , pp. 92-100(9)

Publisher: Bentham Science Publishers

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Abstract:

Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Advanced glycation end products [AGEs] seem to play an important role for the development and/or progression of CVD mainly through induction of oxidative stress and inflammation. AGEs are a heterogenous group of molecules formed by the nonenzymatic reaction of reducing sugars with amino acids of proteins, lipids and nucleic acids. Recent studies suggest that in addition to those endogenously formed, diet constitutes an important exogenous source of AGEs. Diet-derived AGEs contribute to the whole body AGE pool and the AGE-related pathology. Recent in vitro and in vivo studies revealed significant correlations between diet-derived AGEs and several risk factors and/or markers of CVD, suggesting the dietary AGEs restriction as a promising therapeutic intervention.

Keywords: Cardiovascular disease; Atherosclerosis; Oxidative stress; Inflammation; Arterial stiffening; Endothelium; Diet; Advanced glycation end products; AGEs; AGE- receptors

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339908784220732

Publication date: 2008-05-01

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.