Authors: Wandell, Per E.; Theobald, Holger

Source: Current Diabetes Reviews, Volume 3, Number 4, November 2007 , pp. 274-279(6)

Publisher: Bentham Science Publishers

Abstract:

Earlier studies and reviews have shown an association between high fasting blood glucose levels (FBG) and increased mortality. Less is known about the association between low FBG and mortality. This study aimed at reviewing the literature on this topic. A search was performed primarily of Medline through PubMed, and secondarily by searching other databases and using the information from articles already found. Altogether 5 articles meeting the quality demands of the search were found, all supporting the association between low FBG and increased all-cause mortality, with multivariate adjusted hazard ratios between 1.2 and 3.2. Another 22 articles not fulfilling the quality criteria were studied, and actually no study contradicted this association. Most studies were focused on the relation between high FBG and mortality, and did not analyze the association between low FBG and mortality specifically, hence explaining the low number of conclusive articles focusing on this. Thus we conclude, that low FBG is associated with increased mortality, but the cause of this association is unclear. We hypothesize, that low FBG could be a marker of low fat-free mass and low nutrition intake. This topic needs further studies.

Keywords: Blood glucose; Mortality; Follow-up studies; Sweden

Document Type: Research article

Publication date: 2007-11-01

More about this publication?

• Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.
  
  The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.

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