The ATP-Binding Cassette Transporter Subfamily A Member 1 (ABC-A1) and Type 2 Diabetes: An Association Beyond HDL Cholesterol

Authors: Aguilar Salinas, Carlos A.; Cruz-Bautista, Ivette; Mehta, Roopa; Villarreal-Molina, Ma T.; Perez, Francisco J.G.; Tusie-Luna, Ma T.; Canizales-Quinteros, Samuel

Source: Current Diabetes Reviews, Volume 3, Number 4, November 2007 , pp. 264-267(4)

Publisher: Bentham Science Publishers

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Recent findings from several groups demonstrate that ABC-A1 participates in the pathogenesis of the metabolic syndrome and type 2 diabetes. A variant of the ABC-A1 gene (R230C) is associated with the metabolic syndrome and its co-morbidities in Mexicans. Its presence is associated with an increased risk for obesity, the metabolic syndrome and type 2 diabetes. R230C is found exclusively in Amerindian and Amerindian-derived populations. Moreover, animal models confirm the participation of ABC-A1 in the pathogenesis of diabetes. Mice lacking AbcA1 specifically in beta cells had glucose intolerance at 8 weeks of age. The absence of ABC-A1 led to cholesterol accumulation within the beta cell plasma membrane, suggesting that cholesterol may play a role in the insulin secretory pathway. In conclusion, ABC-A1 may be more than a determinant of HDL-cholesterol. It may provide a link between components of the metabolic syndrome and atherosclerosis.

Keywords: ABC A1; Metabolic syndrome; Mexico; Abdominal obesity; LXR

Document Type: Research article

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$54.97 plus tax Refund Policy