Authors: Aguilar Salinas, Carlos A.; Cruz-Bautista, Ivette; Mehta, Roopa; Villarreal-Molina, Ma T.; Perez, Francisco J.G.; Tusie-Luna, Ma T.; Canizales-Quinteros, Samuel

Source: Current Diabetes Reviews, Volume 3, Number 4, November 2007 , pp. 264-267(4)

Publisher: Bentham Science Publishers

Abstract:

Recent findings from several groups demonstrate that ABC-A1 participates in the pathogenesis of the metabolic syndrome and type 2 diabetes. A variant of the ABC-A1 gene (R230C) is associated with the metabolic syndrome and its co-morbidities in Mexicans. Its presence is associated with an increased risk for obesity, the metabolic syndrome and type 2 diabetes. R230C is found exclusively in Amerindian and Amerindian-derived populations. Moreover, animal models confirm the participation of ABC-A1 in the pathogenesis of diabetes. Mice lacking AbcA1 specifically in beta cells had glucose intolerance at 8 weeks of age. The absence of ABC-A1 led to cholesterol accumulation within the beta cell plasma membrane, suggesting that cholesterol may play a role in the insulin secretory pathway. In conclusion, ABC-A1 may be more than a determinant of HDL-cholesterol. It may provide a link between components of the metabolic syndrome and atherosclerosis.

Keywords: ABC A1; Metabolic syndrome; Mexico; Abdominal obesity; LXR

Document Type: Research article

Publication date: 2007-11-01

More about this publication?

• Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.
  
  The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.

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