Neuronal Histamine and its Receptors in Obesity and Diabetes

Authors: Takayuki Masaki,; Hironobu Yoshimatsu,

Source: Current Diabetes Reviews, Volume 3, Number 3, August 2007 , pp. 212-216(5)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $62.88 plus tax (Refund Policy)

Abstract:

Obesity is considered one of the risk factors for metabolic disorders such as diabetes mellitus. There is increasing evidence that obesity and diabetes are under the control of numerous cytokines and hormones, such as adiponectin and leptin. In addition, a number of studies have revealed that the brain functions play a role in the development of obesity and diabetes mellitus. Histamine and its receptors are classical inflammatory mediators in peripheral tissues and also function in the brain. The results of physiological and pharmacological studies revealed that brain histamine and its receptors are involved in the regulation of obesity and diabetes mellitus. Leptin has been shown to regulate obesity and diabetes partially via brain histamine and its receptors. In this review, we focused on the roles of brain histamine and its receptors in regulating obesity and diabetes mellitus.

Keywords: Histamine; Obesity; Histamine H1 receptors; Histamine H3 receptors; Diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339907781369002

Publication date: 2007-08-01

More about this publication?

Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.