“Actin”g on GLUT4: Membrane & Cytoskeletal Components of Insulin Action

Authors: Brozinick, Joseph T.; Berkemeier, Bradley A.; Elmendorf, Jeffrey S.

Source: Current Diabetes Reviews, Volume 3, Number 2, May 2007 , pp. 111-122(12)

Publisher: Bentham Science Publishers

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Abstract:

The dissection of mechanisms that regulate glucose transport by insulin has revealed an intricate network of signaling molecules scattered from the insulin receptor to the intracellular glucose transporter GLUT4. It is also appreciated that some insulin receptor signals jaunt in different directions to regulate events essential for the efficient redistribution of GLUT4 to the plasma membrane. Moreover key assists in the process appear to be arranged by membrane lipids and cytoskeletal proteins. Following current considerations of insulin signals regulating GLUT4, this review will focus on in vitro and in vivo evidence that supports an essential role for phosphoinositides and actin filaments in the control of glucose transport. The discussion will visit recent cell culture, whole animal, and human data highlighting membrane and cytoskeletal aspects of insulin resistance.

Keywords: Diabetes; Glucose transport; Insulin resistance; Signaling; Trafficking

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339907780598199

Affiliations: 1: Eli Lilly and Company, Lilly Corporate Center, Drop Code 0545, Indianapolis, Indiana 46285, USA.

Publication date: 2007-05-01

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.