IngentaConnect The Role of Adipocytokines and Neurohormonal Dysregulation in Met...

Authors: Pik-Shan Kong, Alice; Chan, Norman N.; Chung-Ngor Chan, Juliana

Source: Current Diabetes Reviews, Volume 2, Number 4, November 2006 , pp. 397-407(11)

Publisher: Bentham Science Publishers

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.

Abstract:

Metabolic syndrome, also known as the insulin resistance syndrome (IRS), dysmetabolic syndrome or syndrome X, is a burgeoning global epidemic. This constellation of risk factors, namely glucose intolerance, hypertension, dyslipidemia (high triglyceride and low HDL cholesterol), central obesity, pro-inflammatory and prothrombotic state, culminating to the development of premature cardiovascular and renal disease, has significant impact on life expectancy, societal productivity and quality of life. The underlying mechanism of this complex syndrome remains to be elucidated. In recent years, light has been shed on the roles of neuroendocrine system and adipocytokines on the pathogenesis of IRS. In this review, we summarize the possible links between insulin and various hormones (growth hormones (GH), catecholamines, glucocorticoids and sex hormones), partly mediated through visceral adiposity and adipocytokines (notably adiponectin, leptin, resistin, visfatin, tumor necrosis factor α (TNF-α), interleukin-6 (IL-6)) in the pathogenesis of this syndrome.

The Role of Adipocytokines and Neurohormonal Dysregulation in Metabolic Syndrome