The Role of PTB in Insulin mRNA Stability Control

Authors: G. Fred, Rickard; Tillmar, Linda; Welsh, Nils

Source: Current Diabetes Reviews, Volume 2, Number 3, August 2006 , pp. 363-366(4)

Publisher: Bentham Science Publishers

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Abstract:

Although extensively studied, there are still many unanswered questions regarding the regulation of insulin gene expression. This is important to further investigate since it will help us understand the pathophysiology of some types of diabetes. The insulin mRNA has a long half-life and changes in insulin mRNA stability, induced by glucose, are likely to be regulated through specific mechanisms. Recent findings indicate that the polypyrimidine tract binding protein (PTB), also named hnRNP I, by binding to the 3'-UTR (untranslated region) of the insulin mRNA molecule, stabilizes the messenger thereby participating in the glucose-induced increase in insulin mRNA. This review will focus on recent findings pertinent to PTB subcellular localization and function. It appears that PTB shuttles between the nucleus and the cytosol, and that protein kinase A (PKA)-mediated PTB phosphorylation promotes PTB translocation to the cytosol, an event that might enhance insulin mRNA stability. We will also review beta-cell signaling events that may control the mRNA stabilizing effect of PTB.

Keywords: PTB; hnRNP I; mRNA stability; Insulin gene expression; Diabetes

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339906777950570

Affiliations: 1: Department of Medical Cell Biology, Husargatan 3, S-75123 Uppsala, Sweden.

Publication date: 2006-08-01

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.