Pathophysiology and Treatment of Diabetic Peripheral Neuropathy: The Case for Diabetic Neurovascular Function as an Essential Component

Authors: Kles, Keri A.; Vinik, Aaron I.

Source: Current Diabetes Reviews, Volume 2, Number 2, May 2006 , pp. 131-145(15)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $62.88 plus tax (Refund Policy)

Abstract:

Worldwide, diabetes and its complications are major causes of morbidity, decreased quality of life, mortality and increasing health care costs. Patients with diabetes attempt to control blood pressure, lipids and blood glucose levels to decrease their risk of macrovascular and microvascular complications, such as diabetic peripheral neuropathy (DPN). Even with control of these risk factors for vascular disease, many patients still develop complications. Targeted therapies to the underlying mechanisms of diabetic neuropathy are essential to slow the progression of the disease. This review describes the signs, symptoms and diagnosis of DPN. Additionally, new therapies and the complex etiology that contributes to the development of diabetic neuropathy are described (oxidative stress, hyperglycemia, advanced glycated end products, autoimmunity, neurotrophic factors and protein kinase C β).

Keywords: advanced glycated end product (AGE); Hyperglycaemia; vascular damage; Protein kinase C beta; mitogenactivated protein kinase

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339906776818569

Affiliations: 1: Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 W. Brambleton Ave. Norfolk, VA 23510, USA.

Publication date: 2006-05-01

More about this publication?

Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.