Factors Influencing the Hemodynamic and Metabolic Effects of Insulin in Muscle

Authors: Rattigan, Stephen; Zhang, Lei; Mahajan, Hema; Kolka, Cathryn M.; Richards, Stephen M.; Clark, Michael G.

Source: Current Diabetes Reviews, Volume 2, Number 1, February 2006 , pp. 61-70(10)

Publisher: Bentham Science Publishers

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Abstract:

Insulin mediates its own access and that of glucose to muscle by capillary recruitment and an increase in bulk blood flow. In addition, insulin resistance of muscle may result in part from an impaired hemodynamic action of insulin. The present review examines some of the factors that influence the effects of insulin both at the level of hemodynamics and metabolism in muscle. Factors include fatty acids, the inflammatory cytokine TNFα , vasodilators that relax the blood vessels and increase bulk flow, and elevated blood pressure that may be mediated by endothelin, a potent locally released vasoconstrictor, or other vasoconstrictor influences.

Keywords: Capillary recruitment; Insulin action; Blood flow; Skeletal muscle; Microvascular

Document Type: Research article

Affiliations: 1: Biochemistry, Medical School, Private Bag 58, University of Tasmania, Hobart, TAS 7001, Australia.

Publication date: 2006-02-01

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.