Advanced Glycation End Products (AGEs) and Diabetic Vascular Complications

Authors: Sho-ichi Yamagishi; Kazuo Nakamura; Tsutomu Imaizumi

Source: Current Diabetes Reviews, Volume 1, Number 1, January 2005 , pp. 93-106(14)

Publisher: Bentham Science Publishers

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Abstract:

Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. Chronic hyperglycemia is essentially involved in the development and progression of diabetic micro- and macroangiopathy. Among various metabolic derangements implicated in the pathogenesis of diabetic vascular complication, advanced glycation end product (AGE) hypothesis is most compatible with the theory of 'hyperglycemic memory'. In this review, we discuss the molecular mechanisms of diabetic vascular complication, specially focusing on AGEs and their receptor (RAGE) system. Several types of AGE inhibitors and their therapeutic implications in this devastating disorder are also discussed here.

Keywords: diabetic vascular complications; atherosclerosis; ages; oxidative stress; rage; renin-angiotensin system; insulin resistance; pigment epithelium-derived factor

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1573399052952631

Affiliations: 1: Department of Internal Medicine III, Kurume University School of Medicine, Kurume 830-0011, Japan.

Publication date: 2005-01-01

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Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy.

The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.