Advantages of Nanotechnology- Based Chinese Herb Drugs on Biological Activities

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Abstract:

A number of new nanotechnology-based Chinese herb drugs have been developed that have efficient biopharmaceutical properties and desirable target characteristics. This offers several alternatives for medical applications. Nanoparticles of Chinese herb drugs possess many benefits, such as improving component solubility, enhancement of bioavailability, increasing absorbency of the organism, reducing medicinal herb doses, and achieving steady-state therapeutic levels of drugs over an extended period compared with traditional Chinese herb drug preparations. There are two basic techniques, ‘bottom up’ or ‘top down’, to prepare Chinese herb nanoparticles. Furthermore, specific surface modifications and new design strategies of Chinese herb drug nanoparticles are created to profit clinical applications. This review presents recent advances in nanotechnology-based Chinese herb drugs.





Keywords: Chinese herb drug; Drug carrier; Nanoparticles; Nanotechnology; Target

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/138920009790274603

Publication date: October 1, 2009

More about this publication?
  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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