An Experimental Approach for the Study of Psychotropic Drug Effects Under Simulated Clinical Conditions

Authors: Kudryavtseva, N. N.; Avgustinovich, D. F.; Bondar, N. P.; Tenditnik, M. V.; Kovalenko, I. L.

Source: Current Drug Metabolism, Volume 9, Number 4, May 2008 , pp. 352-360(9)

Publisher: Bentham Science Publishers

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Abstract:

The sensory contact model can induce various different psychopathological states in male mice (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, alcoholism etc.). Additionally, this model facilitates the screening of drugs for therapeutic properties, preventive properties and efficiency under simulated clinical conditions. This approach can reveal the action of drugs at different stages of disease development. It is proposed that this pharmacological approach can be applied for the screening of various novel psychotropic drugs.

Keywords: Sensory contact model; psychotropic drugs; screening

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138920008784220592

Publication date: 2008-05-01

More about this publication?
  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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