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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

Volume 9, Number 1, January 2008
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Articles

Cell Lines: A Tool for In Vitro Drug Metabolism Studies
pp. 1-11(11)
Authors: Gomez-Lechon, M. J.; Donato, M. T.; Lahoz, A.; Castell, J. V.

Strategies to In Vitro Assessment of Major Human CYP Enzyme Activities by Using Liquid Chromatography Tandem Mass Spectrometry
pp. 12-19(8)
Authors: Lahoz, A.; Donato, M. T.; Castell, J. V.; Gomez-Lechon, M. J.

Comparison of Kinetic Parameters for Drug Oxidation Rates and Substrate Inhibition Potential Mediated by Cytochrome P450 3A4 and 3A5
pp. 20-33(14)
Authors: Yamazaki, Hiroshi; Niwa, Toshiro; Murayama, Norie; Emoto, Chie

Epigenetic Regulation of Genes Encoding Drug-Metabolizing Enzymes and Transporters; DNA Methylation and Other Mechanisms
pp. 34-38(5)
Authors: Ieiri, Ichiro; Hirota, Takeshi; Takane, Hiroshi; Higuchi, Shun

The Prediction of the Hepatic Clearance of Tanshinone IIA in Rat Liver Subcellular Fractions: Accuracy Improvement
pp. 39-45(7)
Authors: Wang, Guang-Ji; Li, Peng; Li, Jing; Zhang, Qian; Liu, Xin; Khlentzos, Alexander; Roberts, Michael S.

CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective
pp. 46-59(14)
Author: Lin, Jiunn H.

Recent Advances in the In Silico Modelling of UDP Glucuronosyltransferase Substrates
pp. 60-69(10)
Authors: Sorich, Michael J.; Smith, Paul A.; Miners, John O.; Mackenzie, Peter I.; McKinnon, Ross A.

The UDP-Glucuronosyltransferases as Oligomeric Enzymes
pp. 70-76(7)
Authors: Finel, Moshe; Kurkela, Mika

Metabolic Pathways of T-2 Toxin
pp. 77-82(6)
Authors: Kuca, Kamil; Dohnal, Vlastimil; Jezkova, Alena; Jun, Daniel

Effect of the NMDA-Receptor Antagonist Dextromethorphan in Infant Rat Pneumococcal Meningitis
pp. 83-88(6)
Authors: Leib, Stephen L.; Sellner, Johann; Ringer, Ralph; Baumann, Pierre; Perey, Michel J.; Schmitt, Bernhard

Metabolomics
pp. 89-98(10)
Authors: Gomase, V. S.; Changbhale, S. S.; Patil, S. A.; Kale, K. V.

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