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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

Volume 8, Number 7, October 2007
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Articles

Editorial [Hot Topic: Intestinal First-Pass Metabolism - Bridging the Gap Between In Vitro and In Vivo (Prediction of Intestinal First-Pass Metabolism (Guest Editor: Aleksandra Galetin))]
pp. 643-644(2)
Author: Galetin, Aleksandra

Modeling Gastrointestinal Drug Absorption Requires More In Vivo Biopharmaceutical Data: Experience from In Vivo Dissolution and Permeability Studies in Humans
pp. 645-657(13)
Author: Lennernas, Hans

In Vitro Methods to Study Intestinal Drug Metabolism
pp. 658-675(18)
Authors: van de Kerkhof, Esther G.; de Graaf, Inge A.M.; Groothuis, Geny M.M.

Prediction of Intestinal First-Pass Drug Metabolism
pp. 676-684(9)
Authors: Yang, Jiansong; Jamei, Masoud; Yeo, Karen R.; Tucker, Geoffrey T.; Rostami-Hodjegan, Amin

Maximal Inhibition of Intestinal First-Pass Metabolism as a Pragmatic Indicator of Intestinal Contribution to the Drug-Drug Interactions for CYP3A4 Cleared Drugs
pp. 685-693(9)
Authors: Galetin, Aleksandra; Hinton, Laura K.; Burt, Howard; Obach, R. S.; Houston, J. B.r.i.a.n.

The Role of the Intestine in Drug Metabolism and Pharmacokinetics: An Industry Perspective
pp. 694-699(6)
Authors: Fisher, Michael B.; Labissiere, Gabriel

Small Interfering RNA in Drug Metabolism and Transport
pp. 700-708(9)
Author: Yu, Ai-Ming

Inhibition of Ataxia Telangiectasia-p53-E2F-1 Pathway in Neurons as a Target for the Prevention of Neuronal Apoptosis
pp. 709-715(7)
Authors: Camins, Antoni; Verdaguer, Ester; Folch, Jaume; Beas-Zarate, Carlos; Canudas, Anna M.; Pallas, Merce

Brain Metabolism of Ethanol and Alcoholism: An Update
pp. 716-727(12)
Authors: Hipolito, L.; Sanchez, M. J.; Polache, A.; Granero, L.

Investigation of Xenobiotics Metabolism, Genotoxicity, and Carcinogenicity Using Cyp2e1-/- Mice
pp. 728-749(22)
Authors: Ghanayem, Burhan I.; Hoffler, Undi

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