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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

Volume 8, Number 5, June 2007
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Articles

Editorial
pp. 405-405(1)
Author: Chandra Prakash,

Mechanism-Based Inactivation of Cytochrome P450 Enzymes: Chemical Mechanisms, Structure-Activity Relationships and Relationship to Clinical Drug-Drug Interactions and Idiosyncratic Adverse Drug Reactions
pp. 407-447(41)
Authors: Amit S. Kalgutkar,; R. Scott Obach,; Tristan S. Maurer,

Drug-Drug Interactions via Mechanism-Based Cytochrome P450 Inactivation: Points to Consider for Risk Assessment from In Vitro Data and Clinical Pharmacologic Evaluation
pp. 449-462(14)
Authors: Karthik Venkatakrishnan,; R. Scott Obach,

Evaluation of Human Pharmacokinetics, Therapeutic Dose and Exposure Predictions Using Marketed Oral Drugs
pp. 463-479(17)
Authors: D.F. McGinnity,; J. Collington,; R.P. Austin,; R.J. Riley,

GSTP1 and MTHFR Polymorphisms Are Related with Toxicity in Breast Cancer Adjuvant Anthracycline-Based Treatment
pp. 481-486(6)
Authors: R. Zarate,; S. Gonzalez-Santiago,; J. de la Haba,; E. Bandres,; R. Morales,; J. Salgado,; A. Gomez,; E. Aranda,; J. Garcia-Foncillas,

Genetic Polymorphism of the Flavin-Containing Monooxygenase 3 (FMO3) Associated with Trimethylaminuria (Fish Odor Syndrome): Observations from Japanese Patients
pp. 487-491(5)
Authors: Hiroshi Yamazaki,; Makiko Shimizu,

Phenotyping of Cytochrome P450 2E1 In Vitro and In Vivo
pp. 493-498(6)
Authors: Lena Ernstgard,; Gunnar Johanson,; Anne-Sophie Karlsson,; Margareta Warholm,

Metabolism of Dietary Polyphenols and Possible Interactions with Drugs
pp. 499-507(9)
Authors: Joshua D. Lambert,; Shengmin Sang,; Anthony Y.H. Lu,; Chung S. Yang,

Presystemic Metabolism of Orally Administered Peptide Drugs and Strategies to Overcome It
pp. 509-517(9)
Authors: A. Bernkop-Schnurch,; T. Schmitz,

Calcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants
pp. 519-525(7)
Authors: S.A. Sheweita,; K.I. Khoshhal,

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