Thalidomide Metabolism and Hydrolysis: Mechanisms and Implications

Authors: Lepper, Erin R.; Smith, Nicola F.; Cox, Michael C.; Scripture, Charity D.; Figg, William D.

Source: Current Drug Metabolism, Volume 7, Number 6, August 2006 , pp. 677-685(9)

Publisher: Bentham Science Publishers

Abstract:

Keywords: Hydrolysis; hydroxylation; CYP2C19; pharmacokinetics

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138920006778017777

Affiliations: 1: National Cancer Institute, Building 10, Room 5A01, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Publication date: 2006-08-01

• Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:
  
  In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

• In this: publication
• By this: publisher
• In this Subject: Anatomy & Physiology ,  Pharmacology
• By this author: Lepper, Erin R. ;  Smith, Nicola F. ;  Cox, Michael C. ;  Scripture, Charity D. ;  Figg, William D.

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