Home >> Current Drug Metabolism, Volume 7, Number 3
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Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

Publisher: Bentham Science Publishers

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Volume 7, Number 3, April 2006

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Articles

Reactive Intermediates and the Pathogenesis of Adverse Drug Reactions: The Toxicology Perspective
pp. 219-229(11)
Author: Amacher, David E.

A Literature Review of Enzyme Kinetic Parameters for CYP3A4-Mediated Metabolic Reactions of 113 Drugs in Human Liver Microsomes: Structure- Kinetics Relationship Assessment
pp. 231-249(19)
Author: Bu, H.- Z.

The Impact of In Vitro Binding on In Vitro - In Vivo Extrapolations, Projections of Metabolic Clearance and Clinical Drug-Drug Interactions
pp. 251-264(14)
Authors: Grime, K.; Riley, R. J.

Evaluation of Microsomal Incubation Conditions on CYP3A4-Mediated Metabolism of Cyclosporine A by a Statistical Experimental Design
pp. 265-271(7)
Authors: Hermann, Monica; Kase, Eili T.; Molden, Espen; Christensen, Hege

Candidate Susceptibility Genes in Alzheimer's Disease Are at High Risk for Being Forgotten - They Don't Give Peace of Mind...
pp. 273-293(21)
Authors: Palotas, Andras; Kalman, Janos

Prediction of Maximum Exposure in Poor Metabolizers Following Inhibition of Nonpolymorphic Pathways
pp. 295-299(5)
Authors: Collins, C.; Levy, R.; Ragueneau-Majlessi, I.; Hachad, H.

Involvement of Cytoskeleton in AhR-Dependent CYP1A1 Expression
pp. 301-313(13)
Authors: Dvorak, Zdenek; Vrzal, Radim; Ulrichova, Jitka; Pascussi, Jean-Marc; Maurel, Patrick; Modriansky, Martin

A Critical Evaluation of the Experimental Design of Studies of Mechanism Based Enzyme Inhibition, with Implications for In Vitro-In Vivo Extrapolation
pp. 315-334(20)
Authors: Ghanbari, F.; Rowland-Yeo, K.; Bloomer, J. C.; Clarke, S. E.; Lennard, M. S.; Tucker, G. T.; Rostami-Hodjegan, A.

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