Induction of Cytochromes P450

Author: Schuetz E.G.

Source: Current Drug Metabolism, Volume 2, Number 2, June 2001 , pp. 139-147(9)

Publisher: Bentham Science Publishers

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Abstract:

Humans and rodents are exposed to many foreign compounds in their diet (e.g., herbal supplements such as St. John's wart), in their environment (e.g., organ-ochlorine pesticides and polychorinated biphenyls), and as clinically prescribed drugs (e.g., rifampin and phenobarbital). In response to these exposures mammals have evolved mechanisms to induce proteins involved in xenobiotic detoxification. Metabo-lism by Phase I enzymes, particularly the heme containing monooxygenases- cytochromes P450 is frequently the first line of defense against such xenobiotics.

Keywords: Cytochromes P450; organ-ochlorine pesticides; polychorinated biphenyls; rifampin and phenobarbital; CYP3A; pregnenolone 16alpha-carbonitrile

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389200013338595

Publication date: 2001-06-01

More about this publication?

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.