Induction of Cytochromes P450

Author: Schuetz E.G.

Source: Current Drug Metabolism, Volume 2, Number 2, June 2001 , pp. 139-147(9)

Publisher: Bentham Science Publishers

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Abstract:

Humans and rodents are exposed to many foreign compounds in their diet (e.g., herbal supplements such as St. John's wart), in their environment (e.g., organ-ochlorine pesticides and polychorinated biphenyls), and as clinically prescribed drugs (e.g., rifampin and phenobarbital). In response to these exposures mammals have evolved mechanisms to induce proteins involved in xenobiotic detoxification. Metabo-lism by Phase I enzymes, particularly the heme containing monooxygenases- cytochromes P450 is frequently the first line of defense against such xenobiotics.

Keywords: Cytochromes P450; organ-ochlorine pesticides; polychorinated biphenyls; rifampin and phenobarbital; CYP3A; pregnenolone 16alpha-carbonitrile

Language: English

Document Type: Review article

DOI: 10.2174/1389200013338595

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