Multiple Oxidants in Cytochrome P450 Catalyzed Reactions Implications for Drug Metabolism

Author: Vaz A.D.N.

Source: Current Drug Metabolism, Volume 2, Number 1, March 2001 , pp. 1-16(16)

Publisher: Bentham Science Publishers

Abstract:

The activation of molecular oxygen by Cytochromes P450 to the ultimate mono-oxygen oxidant species involves three distinct dioxygen species coordinated to the heme iron. These intermediates have different chemical properties, and have recently been proposed to participate in some Cytochrome P450- catalyzed oxidation reactions. This article reviews the extent of our current knowledge on the roles proposed for the heme- peroxo, hydroperoxo, and superoxo complexes in various reactions. The extent to which such species contribute to the breadth of reactions catalyzed by Cytochrome P450 has yet to be defined, and more definitive experiments are needed to establish such species in the reactions they are proposed to effect.

Keywords: Multiple Oxidants; Cytochrome P450; Drug Metabolism; Cyp Reactions; Nitric Oxide Synthase; Heme-superoxo; Heme-peroxo; Heme-hydroperoxo; Heme-hydroperoxo; Heme-oxo

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389200013338847

Publication date: 2001-03-01

• Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:
  
  In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.

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• In this Subject: Anatomy & Physiology ,  Pharmacology
• By this author: Vaz A.D.N.

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