Applications of Supercritical Fluid Chromatography-Tandem Mass Spectrometry in Pharmaceuticals

Authors: Bosch, Maria E.; Sanchez, Antonin J.R.; Rojas, Fuensanta S.a.n.c.h.e.z.; Ojeda, Catalina B.o.s.c.h.

Source: Current Drug Discovery Technologies, Volume 6, Number 3, September 2009 , pp. 214-229(16)

Publisher: Bentham Science Publishers

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Abstract:

Supercritical fluid chromatography (SFC) is a fully mature technique and can readily be coupled to mass spectrometers relatively easily. In the last years, supercritical fluid chromatography coupled with mass spectrometry (SFCMS) has had a great advance in productivity, due to increase in reliability and robustness of both SFC and MS systems, the need to push drug discovery faster, and as a potential solution to old problems unsolved and new problems yet to be encountered. This article will illustrate the role of SFC-MS analysis in drug discovery process.

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016309789054942

Publication date: 2009-09-01

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Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.

Current Drug Discovery Technologies is an essential journal for all scientists and research managers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery.