Authors: Sivachenko, Andrey; Kalinin, Andrey; Yuryev, Anton

Source: Current Drug Discovery Technologies, Volume 3, Number 4, December 2006 , pp. 269-277(9)

Publisher: Bentham Science Publishers

Abstract:

The decrease in the drug approval rate by the FDA and the recent failure of some blockbuster drugs has prompted a re-examination of the focus of the pharmaceutical industry on increasing drug selectivity. As a result, it has been proposed that the most efficient cure is in developing promiscuous drugs and selective drug mixtures. Rational design of drug mixtures has been nearly impossible due to the lack of information about in vivo cell regulation, mechanisms of pathway activation, and interactions between different pathways in vivo. We review the current state of the art for rational design of combination therapy and argue that the current industry-wide development of the infrastructure for pathway analysis provides unprecedented opportunity for the rational design of multicomponent and multifunctional drugs. We propose several ways how to use pathway analysis to rationally combine known drugs for either synergizing their efficacy or suppressing individual side effects.

Keywords: tyrosine kinase inhibitor; Pathway analysis; cyclooxegenases; EGF receptor; VEGF

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016306780368117

Affiliations: 1: Application Science Dept.Ariadne Genomics Inc. 9430 Key West avenue, Suite 113, Rockville, MD 20850, USA.

Publication date: 2006-12-01

More about this publication?

• Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.
  
  Current Drug Discovery Technologies is an essential journal for all scientists and research managers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery.

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