Home >> Current Drug Discovery Technologies, Volume 3, Number 3

Prediction of Antigenic Epitopes of Neurotoxin Bmbktx1 from Mesobuthus martensii

Author: Gomase, Virendra S.

Source: Current Drug Discovery Technologies, Volume 3, Number 3, September 2006 , pp. 225-229(5)

Publisher: Bentham Science Publishers

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Abstract:

Gene therapy or recombinant DNA vaccines targeting multiple antigenic components to direct empower the immune system. Antigenic epitopes on neurotoxin Mesobuthus martensii (Buthus martensii) are important determinant of protection against cardiovascular disorder. Small segments 4-YSSDCRVKCVAM-15, 18-SSGKCINSKC-27 of neurotoxin protein called the antigenic epitopes is sufficient for eliciting the desired immune response. In analysis predicted antigenic epitopes neurotoxin protein is seen. Immunization cassettes should be capable of immunizing of broad immunity against both humoral and cellular epitope thus giving vaccines the maximum ability to deal with neurotoxin protein of M. martensii. We have predicted a successful immunization.

Keywords: Neurotoxin; antigenic epitope; GOR; hydrophobicity; hydrophilicity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016306780136817

Affiliations: 1: Department of Bioinformatics,MGMs, College of Computer Science and Information Technology,Nanded, 431605 MS, India.

Publication date: 2006-09-01

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  • Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.

    Current Drug Discovery Technologies is an essential journal for all scientists and research managers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery.
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