Home >> Current Drug Discovery Technologies, Volume 1, Number 4

Mass Spectrometry in Drug Discovery: A Current Review

Author: Wan Y. Feng

Source: Current Drug Discovery Technologies, Volume 1, Number 4, December 2004 , pp. 295-312(18)

Publisher: Bentham Science Publishers

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Abstract:

Drug discovery in the pharmaceutical industry has shown great demands for screening absorption, distribution, metabolism, excretion (ADME) and pharmacokinetics (PK) in guiding the selection of lead candidate compounds. Determination of ADME/PK properties of new chemical entities (NCE) in early drug discovery should allow defects to be corrected prior to time-consuming and expensive preclinical and clinical development stages. Mass spectrometry has evolved to become an irreplaceable technology in all types of drug discovery applications because of its high sensitivity, speed, selectivity, versatility, and ease of automation. This review will include current mass spectrometric techniques and applications in drug discovery, as well as future prospects.

Keywords: mass spectrometry; liquid chromatography; quantitation; qualitation; drugs; metabolites; adme/pk

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570163043334820

Affiliations: 1: PK/DM Department, Mail Stop 4-282, Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608, USA.

Publication date: 2004-12-01

More about this publication?
  • Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.

    Current Drug Discovery Technologies is an essential journal for all scientists and research managers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery.
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