IngentaConnect Rapid Screening of Antioxidants in Pharmaceutical Formulation Dev...

Authors: Huang T.¹; Gao P.¹; Hageman M.J.¹

Source: Current Drug Discovery Technologies, Volume 1, Number 2, June 2004 , pp. 173-179(7)

Publisher: Bentham Science Publishers

Abstract:

Cyclic voltammetry (CV) is a unique technique for the electrochemical characterization of compounds by providing their oxidation / reduction potentials. This technique is widely used in evaluating antioxidants in the oil, food, diagnostic and agricultural industries; however, CV is rarely used in the development of pharmaceutical formulations. This review briefly describes the basic principles of CV and its application in other industries along with the potential and limitations of CV in the rapid evaluation of antioxidants in pharmaceutical formulations. An extensive survey of the literature shows that there is a good correlation between the oxidation potentials of various antioxidants and their antioxidant efficiency. In conclusion, CV should be useful in the development of pharmaceutical formulations where a small group of the preferred antioxidants is rapidly identified. This small group of the most preferred antioxidants can then be employed in a conventional drug stability study thereby providing a rapid approach for the selection of the most suitable antioxidant for a pharmaceutical formulation.

Keywords: Antioxidants; Cyclic Voltammetry

Document Type: Review article

DOI: 10.2174/1570163043335117

Affiliations: 1: Worldwide Pharmaceutical Sciences, Pfizer Inc., Kalamazoo, MI, 49007, USA;

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Rapid Screening of Antioxidants in Pharmaceutical Formulation Development Using Cyclic Voltammetry - Potential And Limitations