Authors: Song, J. C.; Sun, Y. M.; Zhang, M. Z.; Yang, L. Q.; Song, J. G.; Wang, Z. M.; Yu, W. F.

Source: Current Drug Delivery, Volume 6, Number 3, July 2009 , pp. 317-320(4)

Publisher: Bentham Science Publishers

Abstract:

The effect of obstructive jaundice on the distribution and elimination of propofol was studied in 15 patients with obstructive jaundice (total serum bilirubin, TBL ® 17.1μmol.l^-1) and in 15 control patients (TBL < 17.1μmol.l^-1). Following an i.v. bolus dose of propofol (2-2.5 mg.kg^-1) multiple arterial samples were obtained at timed intervals for 4 h and blood concentrations of propofol were measured by high pressure liquid chromatography. Compartmental analysis of propofol concentrations revealed a three-compartment model with elimination from a central compartment in all patients. Pharmacokinelic parameters: volumes of distribution at steady state (V^SS), volumes of distribution at equilibrium (Vr), volumes of the central compartment (V) and total body clearance (Cl) were similar in patients with obstructive jaundice (mean 12.3 (SD 6.0) litre.kg^-1, 32.99(21.42 ) litre.kg-1, 0.241(0.131) litre.kg-1, and 28.8(8.2) ml.min-1.kg^-1 respectively) compared with contro1 group (11.9 (5.4) litre.kg^-1, 28.30(13.70) litre.kg-1, 0.297(0.112) litre.kg-1, and 33.9(7.6) ml.min-1.kg^-1 respectively) (P>0.05). Half-times of the three phases ( T1/2 ^α,T1/2 ^β,T1/2 ^γ) were also similar between both groups.We conclude that in patients with obstructive jaundice the pharmacokinetics of propofol are similar to those of patients without obstructive jaundice.

Keywords: Anaesthetics i.v; propofol; pharmacokinetics; propofol; liver-bile

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156720109788680903

Publication date: 2009-07-01

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• The aim of Current Drug Delivery is to publish peer-reviewed articles, short communications, short and in-depth reviews in the rapidly developing field of drug delivery. Modern drug research aims to build in delivery properties of a drug at the design phase, however in many cases this ideal cannot be met and the development of delivery systems becomes as important as the development as the drugs themselves.
  
  The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.
  
  The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.

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• By this author: Song, J. C. ;  Sun, Y. M. ;  Zhang, M. Z. ;  Yang, L. Q. ;  Song, J. G. ;  Wang, Z. M. ;  Yu, W. F.

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