Drug Delivery Systems Using Immobilized Intact Liposomes: A Comparative and Critical Review

Authors: Brochu H.; Polidori A.; Pucci B.; Vermette P.

Source: Current Drug Delivery, Volume 1, Number 3, July 2004 , pp. 299-312(14)

Publisher: Bentham Science Publishers

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Abstract:

Liposomes sustain considerable interest to develop ways to fabricate drug delivery systems that would provide a good release without inducing any systemic reactions into the host. However, in many cases, liposomes injected into the blood stream are rapidly cleared from the system and only a fraction reaches the target site even when poly(ethylene glycol) (PEG)-coated liposomes are used. Composite drug delivery systems with liposomes i.e., liposomes linked to other substrates can be good candidates for certain type of drug release to achieve a localised treatment.

This paper reviews the fundamental phenomena of the interactions between liposomes and solid substrates. Then, we address various techniques that have been used to immobilize intact liposomes onto and into different substrates. Finally, properties of liposomes used as drug delivery systems are briefly reviewed.

Keywords: liposomes/lipid vesicles; drug delivery systems; surface immobilization of intact liposomes; liposome-collagen entrapment; liposome-chitosan; telomeric liposomes

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1567201043334678

Affiliations: 1: Department of Chemical Engineering, Universite de Sherbrooke, 2500, boul. de l'Universite, Sherbrooke, Quebec, Canada, J1K 2R1

Publication date: 2004-07-01

More about this publication?

The aim of Current Drug Delivery is to publish peer-reviewed articles, short communications, short and in-depth reviews in the rapidly developing field of drug delivery. Modern drug research aims to build in delivery properties of a drug at the design phase, however in many cases this ideal cannot be met and the development of delivery systems becomes as important as the development as the drugs themselves.

The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.

Drug Delivery Systems Using Immobilized Intact Liposomes: A Comparative and Critical Review

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