The Discovery of HPV and its Clinical Implications
Author: Gissmann, Lutz
Source: Current Cancer Therapy Reviews, Volume 6, Number 2, May 2010 , pp. 117-119(3)
Publisher: Bentham Science Publishers
Abstract:About 35 years ago human papillomaviruses (HPV) have been suggested as causative agent for cervical cancer whose infectious etiology had been suggested already many years before. The discovery of the plurality of HPVs encompassing a variety of types with particular biologic properties, the regular presence of the genomes of the so called high-risk types within tumor biopsies, the awareness about the transforming potential of the viral proteins and informative epidemiological surveys led to the consenting view of a causative link between these viruses and cervical cancer and ultimately triggered the development of HPV-specific vaccines for prevention of cervical cancer.
Document Type: Research Article
Publication date: May 2010
- Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.