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Recent Advances in Combined Modality Treatment for Locally Advanced Pancreatic Cancer

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Abstract:

Pancreatic cancer is one of the most resistant cancers to conventional treatment modalities and is generally in the locally advanced or metastatic stage at the time of initial diagnosis. Approximately only 20% of patients are diagnosed as potentially resectable but 5-year survival rate is no more than 20-25% even in these resectable ones.

Realizing the poor prognosis with a single-modality approach, several studies that used the combination of chemotherapy and radiotherapy with surgery are performed in order to improve local control and survival.

This review evaluates the existing data and future aspects about the combined modality treatment in locally advanced pancreatic cancer regarding both the efficiency and toxicity of these combinations and novel agents.

Keywords: adenocarcinoma; chemotherapy; computed tomographic (CT); gemcitabine; intraoperative radiotherapy (IORT); neoadjuvant therapy; pancreaticoduodenectomy; streptozocin

Document Type: Review Article

DOI: https://doi.org/10.2174/157339405774574199

Affiliations: Yahya Kaptan Mahallesi, F 29 Blok Da:12, Kocaeli, Turkey.

Publication date: 2005-11-01

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  • Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.
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