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Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.

Publisher: Bentham Science Publishers

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Volume 6, Number 4, June 2003

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Book Reviews

Review article

Phenotypic Screening of Small Molecule Libraries by High Throughput Cell Imaging
pp. 279-286(8)
Authors: Yarrow J.C.; Feng Y.; Perlman Z.E.; Kirchhausen T.; Mitchison T.J.

A Fluorescent High-Throughput Assay for Double-Stranded DNA: the RediPlate PicoGreen Assay
pp. 287-291(5)
Authors: Batchelor R.; Hagen D.; Johnson I.; Beechem J.

Rapid Assays for Quantitating Cytokine Gene Expression Without Target Amplification
pp. 293-301(9)
Authors: Gonzales F.R.; Lois A.; Sewell T.; LaCerte C.; Gaynor B.; Garcia E.; Jazdzewski M.; Oliver T.; Postor I.; Trainor D.

Assay Development and High-Throughput Screening of Caspases in Microfluidic Format
pp. 303-312(10)
Authors: Ge Wu .; Irvine J.; Luft C.; Pressley D.; Hodge C.Nicholas; Janzen B.

Fluorescence Assays for High-Throughput Screening of Protein Kinases
pp. 313-320(8)
Authors: Zaman G.J.R.; Garritsen A.; Boer T.de; van Boeckel C.A.A.

Competitive Fluorescence Polarization Assays for the Detection of Phosphoinositide Kinase and Phosphatase Activity
pp. 321-330(10)
Authors: Drees B.E.; Weipert A.; Hudson H.; Ferguson C.G.; Chakravarty L.; Prestwich G.D.

Strategies and Solid-Phase Formats for the Analysis of Protein and Peptide Phosphorylation Employing A Novel Fluorescent Phosphorylation Sensor Dye
pp. 331-339(9)
Authors: Martin K.; Steinberg T.H.; Goodman T.; Schulenberg B.; Kilgore J.A.; Gee K.R.; Beechem J.M.; Patton W.F.

Development of Fluorescence-Based Selective Assays for Serine / Threonine and Tyrosine Phosphatases
pp. 341-346(6)
Authors: Pastula C.; Johnson I.; Beechem J.M.; Patton W.F.

Homogeneous Fluorescence Assay for Cyclic AMP
pp. 347-354(8)
Authors: Heyduk E.; Fei Y.; Heyduk T.

Measuring Intracellular Calcium Fluxes in High Throughput Mode
pp. 355-362(8)
Authors: Chambers C.; Smith F.; Williams C.; Marcos S.; Liu Z.Han; Hayter P.; Ciaramella G.; Keighley W.; Gribbon P.; Sewing A.

New Ca2+ Fluoroionophores Based on the BODIPY Fluorophore
pp. 363-366(5)
Authors: Gee K.R.; Rukavishnikov A.; Rothe A.

High Throughput Screening of G-Protein Coupled Receptors via Flow Cytometry
pp. 389-397(9)
Authors: Waller A.; Simons P.; Prossnitz E.R.; Edwards B.S.; Sklar L.A.

Established and Emerging Fluorescence-Based Assays for G-Protein Function: Ras-Superfamily GTPases
pp. 409-418(10)
Authors: Rojas R.J.; Kimple R.J.; Rossman K.L.; Siderovski D.P.; Sondek J.

Addenda

Meet the Guest Editor
pp. 419-419(1)
Author: Gee K.R.

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