Automated Parallel Solid-Phase Synthesis of Non-Peptide CCR1 Receptor Antagonists

Authors: Buckman B.O.; Ghannam A.; Li A.; Liang M.; Mohan R.; Ng H.P.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 3, May 2002 , pp. 249-251(4)

Publisher: Bentham Science Publishers

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Abstract:

An automated, parallel, solid-phase synthesis and screening strategy using commercially available aryl acetic acids as starting materials has discovered novel, non-peptide CCR1 antagonists (Ki < 100 nM).

Keywords: solid-phase synthesis; ccri receptor antagonist

Language: English

Document Type: Review article

DOI: 10.2174/1386207024607284

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