Developing Soluble Polymers for High-Throughput Synthetic Chemistry

Authors: Spanka C.; Wentworth Jr P.; Janda K.D.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 3, May 2002 , pp. 233-240(8)

Publisher: Bentham Science Publishers

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Abstract:

Soluble polymers have emerged as viable alternatives to resin supports across the broad spectrum of high-throughput organic chemistry. As the application of these supports become more widespread, issues such as broad-spectrum solubility and loading are becoming limiting factors and therefore new polymers are required to overcome such limitations. This article details the approach made within our group to new soluble polymer supports and specifically focuses on parallel libraries of block copolymers, de novo poly(styrene-cochloromethylstyrene), PEG-‘stealth’ stars, and substituted poly(norbornylene)s.

Keywords: soluble polymer support; block copolymer; peg-stealth star; poly(norbornylene)

Language: English

Document Type: Review article

DOI: 10.2174/1386207024607239

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