The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

Authors: Organ M.G.; Dixon C.E.; Mayhew D.; Parks D.J.; Arvanitis E.A.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 3, May 2002 , pp. 211-218(8)

Publisher: Bentham Science Publishers

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Abstract:

The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect ‘catch and release’ purification across these diverse libraries is highlighted.

Keywords: molecular library; solution phase method; ptbd resin; scx

Language: English

Document Type: Review article

DOI: 10.2174/1386207024607301

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