The Use of a Supported Base and Strong Cation Exchange (SCX) Chromatography to Prepare a Variety of Structurally-Diverse Molecular Libraries Prepared by Solution-Phase Methods

Authors: Organ M.G.; Dixon C.E.; Mayhew D.; Parks D.J.; Arvanitis E.A.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 3, May 2002 , pp. 211-218(8)

Publisher: Bentham Science Publishers

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Abstract:

The preparation of molecular libraries of aminomethylbiaryls, allylic amines, and ethanolamines using solution-phase methodology is described. In particular, the use of a solid-supported base reagent (PTBD resin) and strong cation exchange(SCX) resin to effect ‘catch and release’ purification across these diverse libraries is highlighted.

Keywords: molecular library; solution phase method; ptbd resin; scx

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207024607301

Publication date: 2002-05-01

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Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.