High-throughput Chemistry toward Complex Carbohydrates and Carbohydrate-like Compounds a

Authors: Randell K.D.; Barkley A.; Arya P.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 2, March 2002 , pp. 179-193(15)

Publisher: Bentham Science Publishers

Abstract:

In the area of peptide and nucleic acid chemistry and biology, high-throughput synthesis has played an important role in providing useful small-molecule-based chemical probes in understanding the structure and function relationships. The past several years, there has been a constant rise in interest toward understanding the biological roles and functions of another important class of biomolecules, i.e., carbohydrates and carbohydrate conjugates. Although at early stages, in recent years, several groups have developed high-throughput synthetic methods to obtain complex carbohydrates or carbohydrate-like small-molecules. The present review article summarizes some of these developments.

Keywords: carbohydrates; carbohydrate-like compounds; biomolecules; carbohydrate conjugates; glycoproteins; glycolipids; oligosac-charides; carbodrate scaffolida; multiple component condensation(mcc); glycohy brids

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207024607374

Publication date: 2002-03-01

• Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.

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