Rapid Determination of Pharmacokinetic Properties of New Chemical Entities: In vivo Approaches

Authors: Cox K.A.; White R.E.; Korfmacher W.A.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 1, February 2002 , pp. 29-37(10)

Publisher: Bentham Science Publishers

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Abstract:

There is a continuing need for increased throughput in the evaluation of new chemical entities in terms of their pharmacokinetic (PK) parameters as part of new drug discovery. This review summarizes various approaches that have been used to increase throughput in this area. The article divides the approaches into two areas: assay enhancement and sample reduction.

Keywords: Pharmacokinetic pk; drug discovery; solid phase extraction spe

Language: English

Document Type: Review article

DOI: 10.2174/1386207023330534

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