IngentaConnect Mimotopes of Viral Antigens and Biologically Important Molecules ...

Authors: Partidos C.D.; Steward M.W.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 1, February 2002 , pp. 15-27(13)

Publisher: Bentham Science Publishers

Abstract:

Antigen recognition by antibodies or ligand-receptor interactions involve small areas of the molecule named epitopes that are normally conformational in nature. The availability of combinatorial peptide libraries has provided a powerful tool for selecting novel sequences which mimic conformational epitopes (mimotopes) either structurally and / or immunologically. These mimotopes can be particularly useful in a number of situations, including: the development of vaccines against tumors, infectious diseases or allergic conditions the design of molecules which can act as agonists or antagonists of various biologically-important molecules and for the development of diagnostic assays. This article reviews the authors' work on the application of combinatorial peptide libraries to identify mimotopes of protective B-cell epitopes from various pathogens, and the search for molecules able to block the biological activities of TNF- agr , a cytokine which plays a key role in inflammation.

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Mimotopes of Viral Antigens and Biologically Important Molecules as Candidate Vaccines and Potential Immunotherapeutics