Mimotopes of Viral Antigens and Biologically Important Molecules as Candidate Vaccines and Potential Immunotherapeutics

Authors: Partidos C.D.; Steward M.W.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 1, February 2002 , pp. 15-27(13)

Publisher: Bentham Science Publishers

Abstract:

Antigen recognition by antibodies or ligand-receptor interactions involve small areas of the molecule named epitopes that are normally conformational in nature. The availability of combinatorial peptide libraries has provided a powerful tool for selecting novel sequences which mimic conformational epitopes (mimotopes) either structurally and / or immunologically. These mimotopes can be particularly useful in a number of situations, including: the development of vaccines against tumors, infectious diseases or allergic conditions the design of molecules which can act as agonists or antagonists of various biologically-important molecules and for the development of diagnostic assays. This article reviews the authors' work on the application of combinatorial peptide libraries to identify mimotopes of protective B-cell epitopes from various pathogens, and the search for molecules able to block the biological activities of TNF-, a cytokine which plays a key role in inflammation.

Keywords: Mimotopes; Viral Antigens; epitopes; measles virus mv; respiratory syncytial virus rsv; schistosoma mansoni; mouth disease virus fmdv

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207023330589

Publication date: 2002-02-01

• Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.

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