Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules

Authors: Adda C.G.; Anders R.F.; Tilley L.; Foley M.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 5, Number 1, February 2002 , pp. 1-14(14)

Publisher: Bentham Science Publishers

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Abstract:

Phage display has become a widely used tool for the identification of proteins or peptides with affinity for a variety of biomolecules. The versatility, simplicity and cost effectiveness of this application has pervaded a wide variety of research areas. Although not without its limitations, phage display has provided a convenient methodology for obtaining ligands to study the function, structure and diagnostic or therapeutic potential of various macromolecules. This review highlights some recent research employing this technology that serves to illustrate its utility in various research and clinical applications.

Keywords: Phage display; biopannig; tissue-type plasminogen activator

Language: English

Document Type: Review article

DOI: 10.2174/1386207023330561

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