Qualitative and Quantitative Analyses of Resin-Bound Organic Compounds

Authors: Irving M.; Cournoyer J.; Li R.; Santos C.; Yan B.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 4, Number 4, June 2001 , pp. 353-362(10)

Publisher: Bentham Science Publishers

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Abstract:

Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.

Keywords: Resin-Bound Organic Compounds; UV-Vis spectra; Gel-phase 19F NMR; Dansylhydrazine; Fourier Transform infrared; Hydroxybenzotriazole hydrate; Nuclear magnetic resonance; Tetrahydrofuran; Diisopropylethylamine; hexafluorophosphate

Language: English

Document Type: Review article

DOI: 10.2174/1386207013331066

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