High Resolution Magic Angle Spinning NMR in Combinatorial Chemistry

Authors: Lippens G.; Warrass R.; Wieruszeski J.M.; Rousselot-Pailley P.; Chessari G.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 4, Number 4, June 2001 , pp. 333-351(19)

Publisher: Bentham Science Publishers

Abstract:

Solid phase organic chemistry coupled with combinatorial methods promises to increase dramatically the diversity and number of small molecules available for medical and biological applications. However, optimizing the reaction conditions can be a time consuming step, especially since analytical tools to monitor reaction progress and detect impurities for solid phase chemistry are less developed than for solution chemistry. The use of high resolution magic angle spinning (HRMAS) NMR is described here as such an analytical tool. Whereas initial applications of molecular identification using deuterated organic solvents to swell the resins presented a significant gain in time over the cleave-and- analysis methods, the introduction of a differential diffusion filter has made immediate recording of spectra possible without any sample treatment. The applications of HRMAS NMR to different solid supports that are used in combinatorial chemistry will be described in terms of rapidity, robustness and sensitivity.

Keywords: Magic Angle Spinning; 1D proton spectrum; microscopic magnetization vector; Carr-Purcell-Meiboom-Gill sequence; Dimethyl formamide; Fourier Transform infrared; Hydroxymethylbenzoic acid; Isoleucine; Nuclear magnetic resonnance; Pyroglutamic acid; Solid phase organic chemistry; Total correlation spectroscopy

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207013331048

Publication date: 2001-06-01

• Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.

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• By this author: Lippens G. ;  Warrass R. ;  Wieruszeski J.M. ;  Rousselot-Pailley P. ;  Chessari G.

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