On-line Sample Preparation for High Throughput Reversed-phase LC / MS Analysis of Combinatorial Chemistry Libraries.

Authors: Tang L.; Fitch W.L.; Smith P.; Tumelty D.; Cao K.; Ferla S.W.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 4, Number 3, May 2001 , pp. 287-293(7)

Publisher: Bentham Science Publishers

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Abstract:

An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography / mass spectrometry (LC / MS). This approach is particularly helpful for the LC / MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.

Keywords: High Throughput Reversed; Combinatorial Chemistry Libraries; liquid chromatography; Reversed Phase HPLC Columns; dioctyl phthalate; CTC syringe; TentaGel

Language: English

Document Type: Review article

DOI: 10.2174/1386207013331110

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