Enantioseparations Using Cellulose Tris(3,5-dichlorophenylcarbamate) During High-performance Liquid Chromatography with Analytical and Capillary Columns Potential for Screening of Chiral Compounds

Authors: Chankvetadze B.; Yamamoto C.; Okamoto Y.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 6, December 2000 , pp. 497-508(12)

Publisher: Bentham Science Publishers

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Abstract:

The appropriate selection of the mobile phase facilitated the use cellulose tris(3,5-dichlorophenylcarbamate (CDCPC) as a chiral stationary phase (CSP) during high-performance liquid chromatography (HPLC). A preliminary evaluations of this material indicated its very high chiral resolving ability toward many analytes of different chemical and pharmacological groups. Some chemicals and drugs containing two centers of chirality were also successfully resolved into all possible stereoisomers. The applicability of CDCPC for enantioseparations in capillary liquid chromatography was also shown giving promising prospects for the screening of novel biologically active compounds (which may be also synthesized based on combinatorial strategies) for their enantiomeric composition.

Keywords: Enantioseparation; Liquid Chromatography; Chiral Compounds; Microcrystaline cellulose; Macroporous silica gel; Chromatographic sepration; Capillary electrochromatograohy

Language: English

Document Type: Review article

DOI: 10.2174/1386207003331391

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