Screening Procedures for Simultaneous Detection of Several Drug Classes Used for High Throughput Toxicological Analyses and Doping Control. A Review

Author: Maurer H.H.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 6, December 2000 , pp. 467-480(14)

Publisher: Bentham Science Publishers

Abstract:

This paper reviews high throughput screening procedures for the simultaneous detection of several drug classes relevant to clinical and forensic toxicology or doping control in urine or blood using gas chromatography-mass spectrometry (GC-MS), liquid chromatography coupled with a diode-array detector (LC-DAD) or mass spectrometry (LC-MS). Basic information describing these systematic toxicological analysis (STA) procedures such as the analytes, the biosample, work-up, separation column, mobile phase or separation buffer, detection mode and detection limits are summarized in tables arranged according to the analytical method. Examples of typical applications are presented in 2 figures. Analysis of alternative matrices, like sweat, saliva, nails or hair, was not reviewed.

Keywords: Throughput Toxicological Analyses; Liquid chromatography; STA procedures; Liquid liquid extraction; Toxicology analyses; Toxicological analyses; Intramolecular transesterrification; Mass chromatograms; Extractive methylation; DAD detection

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207003331355

Publication date: 2000-12-01

• Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.

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