High Throughput and Global Approaches to Gene Expression

Author: Ghosh D.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 5, October 2000 , pp. 411-420(10)

Publisher: Bentham Science Publishers

Abstract:

In the past several years, a new set of technologies based on whole genome analysis have revolutionized the study of gene expression. These microarray or "gene chip" technologies, which arose out of the development of large-scale sequencing approaches, are now coming into increasing use, generating a far greater volume of data than the data representing the sequences themselves. This review focuses on the current state of development of these technologies, and the available approaches to manage and analyze the information they generate. The applicability of this technology to general problems in biomedicine is also discussed.

Keywords: Gene Expression; Gene Chip; Transcriptome; Yeast Transcriptome; Interferons; Radiation Stress; Inflammatory Associated Gene; Muscle-Specific Gene Expression; Neuronal Development; Cystic Fibrosis; Cancers; Data Management; Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Human Mammary Epithelial Carcinoma; Self-Organizing Map; Support Vector Machine

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207003331481

Publication date: 2000-10-01

• Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.

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