A Merger of Rational Drug Design and Combinatorial Chemistry Development and Application of Peptide Secondary Structure Mimetics

Authors: Kim H-O.; Kahn M.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 3, June 2000 , pp. 167-183(17)

Publisher: Bentham Science Publishers

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Abstract:

Recent efforts toward the development of peptide secondary structure mimetics at Molecumetics Ltd. for the discoveries of new drug candidates utilizing combinatorial chemistry with solid phase synthesis are described.

Keywords: Drug design; Combinatorial Chemistry; Peptide secondary structure mimetis; Proteases; Cytokines

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207003331625

Publication date: 2000-06-01

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Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.