Chromatography-Free Synthesis of 1,2,4-Oxadiazoles Using ROMPGEL-Supported Acylating Reagents

Authors: Barrett A.G.M.; Cramp S.M.; Roberts R.S.; Zecri F.J.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 2, April 2000 , pp. 131-138(8)

Publisher: Bentham Science Publishers

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Abstract:

1,2,4-Oxadiazoles were synthesized in solution from aromatic amidoximes and acylating agents supported on a ring opening metathesis polymer (ROMPGEL) backbone. High yields and purities of the 1,2,4-oxadiazoles were obtained with minimal purification.

Keywords: Chromatography free synthesis; Acylating reagents; 1,2,4 oxadiazoles; Ring opening metathesis polymer; Polymers ROMPGELs

Language: English

Document Type: Regular paper

DOI: 10.2174/1386207003331733

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