Chemoselective High-Throughput Purification Mediated by Solid-Supported Reagents Its Application to the First 6,9-Disubstituted Purine Library Synthesis

Authors: Kim K.; McComas W.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 2, April 2000 , pp. 125-129(5)

Publisher: Bentham Science Publishers

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Abstract:

A new application of solid-supported reagents was developed to separate the alkylated N7 N9 regioisomers derived from commercially available 2-amino-6-chloropurine. Simple filtration through an alumina H positive pad or scavenging by AG Dowex-50W-X8 resin provides diverse N9 regioisomers selectively in moderate yields with high purities (less than90 percent). This purification method can be conveniently used in a high-throughput format and facilitates the synthesis of a purine library without laborious regioisomer separation and aqueous work-up. The first library synthesis of 6,9-disubstituted purines is reported using the combination of this novel separation method in conjunction with polymer-supported reagents.

Keywords: Chemoselective High throughput purification; Solid supported reagents; 6,9 disubstituted purine library synthesis

Language: English

Document Type: Regular paper

DOI: 10.2174/1386207003331779

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